Political Campaigning: Where Scientific and Ethical Arguments Meet Public Policy

The ambition of the paradigm shift we seek is vast, and the obstacles we face are intractable. For anyone opposing the use of non-human animals (hereinafter referred to as animals) in research and testing, the story has been the same from the start. Legitimate concern for animals has been all-too-easily dismissed as misguided sentimentality, and powerful vested interests have claimed scientific, economic, and moral superiority. But the ground is shifting. Animal researchers accept the need to provide scientific justification for their choices, and the protection of animals is increasingly recognized as a public good. Concern among citizens has been translated into hard-and-fast rules, and scientific advances have added weight to the growing demand for change. In deciding how best to achieve the paradigm shift, the question for animal advocates is how to create the greatest change in the shortest time possible. This chapter deals with political campaigning at the European Union (EU) level, since the adoption of the first EU Directive on the protection of animals used for scientific purposes, and focuses on the main political developments of the past two decades. Historically, much was made of a perceived choice between presenting ethical or scientific arguments; both are powerful drivers, providing evidence that existing practice is flawed. Other chapters in this Volume describe aspects of those approaches in detail; similarly, the question of whether to focus on the 3Rs or replacement only is also covered elsewhere. In this chapter, a pragmatic policy focus is necessary to explore how scientific and ethical objectives can be pursued in order to move forward in the political arena, making full use of existing structures and creating new opportunities. The stakes are high. Our vision requires a revolution in science and in the way animals are treated. Twenty-first century technology should not depend on inhumane practices, just as modern economies should not depend on the destruction of the environment or the exploitation of workers

Political Campaigning: Where Scientific and Ethical Arguments Meet Public Policy

The ambition of the paradigm shift we seek is vast, and the obstacles we face are intractable. For anyone opposing the use of non-human animals (hereinafter referred to as animals) in research and testing, the story has been the same from the start. Legitimate concern for animals has been all-too-easily dismissed as misguided sentimentality, and powerful vested interests have claimed scientific, economic, and moral superiority. But the ground is shifting. Animal researchers accept the need to provide scientific justification for their choices, and the protection of animals is increasingly recognized as a public good. Concern among citizens has been translated into hard-and-fast rules, and scientific advances have added weight to the growing demand for change. In deciding how best to achieve the paradigm shift, the question for animal advocates is how to create the greatest change in the shortest time possible. This chapter deals with political campaigning at the European Union (EU) level, since the adoption of the first EU Directive on the protection of animals used for scientific purposes, and focuses on the main political developments of the past two decades. Historically, much was made of a perceived choice between presenting ethical or scientific arguments; both are powerful drivers, providing evidence that existing practice is flawed. Other chapters in this Volume describe aspects of those approaches in detail; similarly, the question of whether to focus on the 3Rs or replacement only is also covered elsewhere. In this chapter, a pragmatic policy focus is necessary to explore how scientific and ethical objectives can be pursued in order to move forward in the political arena, making full use of existing structures and creating new opportunities. The stakes are high. Our vision requires a revolution in science and in the way animals are treated. Twenty-first century technology should not depend on inhumane practices, just as modern economies should not depend on the destruction of the environment or the exploitation of workers

Towards a 21st-century roadmap for biomedical research and drug discovery:consensus report and recommendations

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies, and the corporate and nongovernmental organisation (NGO) sectors, in this consensus report, we analyse, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathway-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this

2018 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1005/thumbnail.jp

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

Reducing supply chain environmental uncertainty through e-intermediation: An organisation theory perspective

Organisation theorists have long been aware of the organisational problems caused by environmental uncertainty. Recently supply chain theorists have identified the same issue for supply chains. It is the premise of this paper that one possible way of reducing these problems is through the use of e-intermediation. The paper seeks support for this premise by synthesising relevant literature on the nature and origins of e-intermediation with organisation theory literature particularly with respect to the negative impact of environmental uncertainty. From this four propositions concerning the ways that e-intermediation can reduce the negative effects of environmental uncertainty in the supply chain are developed. The appropriateness of these propositions is then examined through the analysis of three case studies of supply chains that have introduced e-intermediation. The evidence from the case studies supports the propositions and from their evidence conclusions about the potential of e-intermediation to reduce the negative effects of environmental uncertainty on supply chains are drawn. However, the paper also draws attention to the possibility that certain factors, even in uncertain environments, may impede the beneficial impact of e-intermediation on supply chain performance. Finally the paper notes some managerial and research implications of the study.

Implementing practice guidelines: A workshop on guidelines dissemination and implementation with a focus on asthma and COPD

The present supplement summarizes the proceedings of the symposium “Implementing practice guidelines: A workshop on guidelines dissemination and implementation with a focus on asthma and COPD”, which took place in Quebec City, Quebec, from April 14 to 16, 2005. This international symposium was a joint initiative of the Laval University Office of Continuing Medical Education (Bureau de la Formation Médicale Continue), the Canadian Thoracic Society and the Canadian Network for Asthma Care, and was supported by many other organizations and by industrial partners. The objectives of this meeting were to examine the optimal implementation of practice guidelines, review current initiatives for the implementation of asthma and chronic obstructive pulmonary disease (COPD) guidelines in Canada and in the rest of the world, and develop an optimal strategy for future guideline implementation. An impressive group of scientists, physicians and other health care providers, as well as policy makers and representatives of patients’ associations, the pharmaceutical industry, research and health networks, and communications specialists, conveyed their perspectives on how to achieve these goals

The complete mitochondrial genome of the brown pansy butterfly, Junonia stygia (Aurivillius, 1894), (Insecta: Lepidoptera: Nymphalidae)

The brown pansy, Junonia stygia (Aurivillius, 1894) (Lepidoptera: Nymphalidae), is a widespread West African forest butterfly. Genome skimming by Illumina sequencing allowed assembly of a complete 15,233 bp circular mitogenome from J. stygia consisting of 79.5% AT nucleotides. Mitochondrial gene order and composition is identical to other butterfly mitogenomes. Junonia stygia COX1 features an atypical CGA start codon, while ATP6, COX1, COX2, ND4, and ND4L exhibit incomplete stop codons. Phylogenetic reconstruction supports a monophyletic Subfamily Nymphalinae, Tribe Junoniini, and genus Junonia. The phylogenetic tree places Junonia iphita and J. stygia as basal mitogenome lineages sister to the remaining Junonia sequences